Developmental Changes in Rabbit Juxtamedullary Proximal Convoluted Tubule Acidification
نویسندگان
چکیده
منابع مشابه
Neonatal rabbit juxtamedullary proximal convoluted tubule acidification.
The present in vitro microperfusion study examined apical membrane Na+/H+ antiporter and basolateral membrane Na(HCO3)3 symporter activity in newborn and adult juxtamedullary proximal convoluted tubules. Proton fluxes were determined from the initial rate of change of intracellular pH after a change in the luminal or bathing solution, buffer capacity, and tubular volume of newborn and adult tub...
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Glucocorticoids have an important role in renal acidification; however, a direct effect of glucocorticoids on proximal convoluted tubule (PCT) acidification has not been directly demonstrated. In the present in vitro microperfusion study PCT from animals receiving dexamethasone (600 micrograms/kg twice daily for 2 d and 2 h before killing) had a significantly higher rate of bicarbonate absorpti...
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This in vitro microperfusion study examined the effects of growth hormone and insulin-like growth factor I (IGF-I) on proximal convoluted tubule (PC1) transport. Tubules were perfused with an ultrafiltrate-like solution and bathed in a serumlike albumin solution. Neither a physiologic (5 X 10-10 M), nor a pharmacologic (5 X 10jM) dose of growth hormone had an effect on PCT phosphate or bicarbon...
متن کاملDevelopmental Changes in Rabbit Proximal Straight Tubule
The early proximal tubule preferentially reabsorbs organic solutes and bicarbonate over chloride ions resulting in a luminal fluid with a higher chloride concentration than that in blood. From this late proximal tubular fluid, half of NaCl reabsorption by the adult proximal tubule is active and transcellular and half is passive and paracellular. The purpose of the present in vitro microperfusio...
متن کاملDevelopmental changes in rabbit proximal straight tubule paracellular permeability.
The early proximal tubule preferentially reabsorbs organic solutes and bicarbonate over chloride ions, resulting in a luminal fluid with a higher chloride concentration than that in blood. From this late proximal tubular fluid, one-half of NaCl reabsorption by the adult proximal tubule is active and transcellular and one-half is passive and paracellular. The purpose of the present in vitro micr...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1992
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199204000-00021